epitope mapping at the N-terminus of Smad7 of human origin
recommended for detection of Smad6 and Smad7 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
blocking peptide, sc-7004 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-7004 X, 200 µg/0.1 ml
Smad6/7 Background Information Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad family members.
Smad6/7 (N-19) Product Citations
See how others have used Smad6/7 (N-19): sc-7004 antibody and or Smad6/7 (N-19) antibody conjugates.
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Smad6/7 (N-19)
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Smad6/7 (N-19): sc-7004. Western blot analysis of non-transfected (A) and Smad7-transfected (B) COS cells.
Smad6/7 (N-19): sc-7004. Western blot analysis of Smad6 expression in non-transfected: sc-117752 (A) and mouse Smad6 transfected: sc-123643 (B) 293T whole cell lysates.
Smad6/7 (N-19): sc-7004. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
