santa cruz biotechnology, inc.
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α T-catenin (4A21) Antibody: sc-69968 |
| Datasheet |
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- mouse monoclonal IgG2a, 200µg/ml
- raised against amino acids 164-177 of αT-catenin of human origin
- recommended for detection of α T-catenin of human origin by WB and IF; non cross-reactive with α E-catenin or α N-catenin
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
CTNNA3 |
29119 |
10q21.3 |
NM_013266 |
Q9UI47
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607667 |
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α T-catenin Background Information
The catenins (å, ∫, © and ∂) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. å T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantally expressed in cardiomyocytes and in the peritubular myoid cells of the testis. å T-catenin binds to å E-catenin as well as to ∫-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for å-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer's disease (LOAD) as well as to dilated cardiomyopathy. |
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