Hep C cAg (1868) Antibody: sc-69937

Hep C cAg Background Information
The Hep C (hepatitis C) is a small, enveloped, single-stranded, positive sense RNA virus belonging to the family Flaviviridae. Transmission of the virus occurs when blood from an infected individual enters the body of an uninfected individual. Hep C primarily replicates within hepatocytes in the liver, and circulating Hep C particles bind to receptors on the surface and enter these cells. Hep C replicates quickly, producing approximately one trillion particles each day in infected individuals. Hep C RNA polymerase has no proofreading function, so the virus has an exceptionally high mutation rate which may help it elude the immune system of the host. Hep C infection results in chronic infections, liver cirrhosis and hepatocellular carcinoma in most people. The core protein of Hep C, known as Hep C cAg, is well conserved among the different viral genotypes and may contribute to the hepatic fibrogenesis by up-regulating connective tissue growth factor and TGF∫1.