GPS2 Background Information The N-Cor-HDAC3 repressor complex inhibits the JNK pathway, which is involved in cell differentiation and apoptosis and responds to stress stimuli. G protein pathway suppressor 2 (GPS2), also referred to as AMF1, is an integral component of the N-Cor-HDAC3 complex and functions to suppress G-protein and MAP kinase-mediated signal transduction. The N-Cor complex inhibits the JNK pathway, a pathway that is involved in cell differentiation and apoptosis and responds to stress stimuli. TBL1, another component of the complex, interacts with GPS2 to form a heterotrimeric structure. GPS2 can also stimulate the activity of cellular transcription factors including the human papilloma virus E2 and E6 proteins, as well as p53. Amplified expression of GPS2 may augment p53-dependent transcription, causing a G(1) arrest in cells.
GPS2 (1E2)
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GPS2 (1E2): sc-69707. Western blot analysis of GPS2 expression in HeLa whole cell lysate.
GPS2 (1E2): sc-69707. Western blot analysis of GPS2 expression in A-673 nuclear extract.
