c-Rel Antibody (B-6): sc-6955
- c-Rel Antibody (B-6) is a mouse monoclonal IgG1 λ c-Rel antibody, cited in 132 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of c-Rel of human origin
- c-Rel Antibody (B-6) is recommended for detection of c-Rel p75 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-c-Rel Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-6955 X, 200 µg/0.1 ml)
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for c-Rel Antibody (B-6) for WB and IHC(P) applications. This reagent is now offered in a bundle with c-Rel Antibody (B-6) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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c-Rel Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects c-Rel of mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry (IHC). c-Rel Antibody (B-6) is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. c-Rel is a vital component of the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) signaling pathway, which is essential for regulating immune responses, cell proliferation, and survival. Through binding to specific κB sites in promoter regions of target genes, c-Rel plays a crucial role in transcriptional activation of immunoglobulin kappa light chain genes, thereby influencing B cell development and function. Proper regulation of c-Rel is important because dysregulation can lead to various immune disorders and contribute to cancer development. In contrast to v-Rel, which lacks a functional C-terminal transactivation domain and disrupts normal NFκB signaling, c-Rel maintains a role as a transcriptional activator, highlighting significance in maintaining cellular homeostasis and immune function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
c-Rel Antibody (B-6) References:
- Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. | Chen, Y., et al. 2004. Mol Cell Biol. 24: 3048-56. PMID: 15024091
- c-rel activates but v-rel suppresses transcription from kappa B sites. | Inoue, J., et al. 1991. Proc Natl Acad Sci U S A. 88: 3715-9. PMID: 2023921
- Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. | Ghosh, S., et al. 1990. Cell. 62: 1019-29. PMID: 2203532
- The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. | Bull, P., et al. 1990. Mol Cell Biol. 10: 5473-85. PMID: 2204816
- Transactivation of gene expression by nuclear and cytoplasmic rel proteins. | Hannink, M. and Temin, HM. 1989. Mol Cell Biol. 9: 4323-36. PMID: 2555689
- c-Rel and its many roles in cancer: an old story with new twists. | Hunter, JE., et al. 2016. Br J Cancer. 114: 1-6. PMID: 26757421
- Transcriptional autoregulation of the proto-oncogene fos. | Sassone-Corsi, P., et al. 1988. Nature. 334: 314-9. PMID: 2839774
- Different localization of the product of the v-rel oncogene in chicken fibroblasts and spleen cells correlates with transformation by REV-T. | Gilmore, TD. and Temin, HM. 1986. Cell. 44: 791-800. PMID: 3004745
- c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis. | Leslie, J., et al. 2020. Nat Metab. 2: 1350-1367. PMID: 33168981
- c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis. | Leslie, J., et al. 2023. Hepatology. 78: 1050-1063. PMID: 36089330
- Isolation and characterization of reticuloendotheliosis virus transformed bone marrow cells. | Franklin, RB., et al. 1974. Intervirology. 3: 342-52. PMID: 4443191
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
c-Rel Antibody (B-6) | sc-6955 | 200 µg/ml | $322.00 | |||
c-Rel Antibody (B-6): m-IgGλ BP-HRP Bundle | sc-520482 | 200 µg Ab, 40 µg BP | $361.00 | |||
c-Rel Antibody (B-6) X | sc-6955 X | 200 µg/0.1 ml | $322.00 | |||
c-Rel Antibody (B-6) AC | sc-6955 AC | 500 µg/ml, 25% agarose | $424.00 | |||
c-Rel Antibody (B-6) HRP | sc-6955 HRP | 200 µg/ml | $322.00 | |||
c-Rel Antibody (B-6) FITC | sc-6955 FITC | 200 µg/ml | $336.00 | |||
c-Rel Antibody (B-6) PE | sc-6955 PE | 200 µg/ml | $349.00 | |||
c-Rel Antibody (B-6) Alexa Fluor® 488 | sc-6955 AF488 | 200 µg/ml | $364.00 | |||
c-Rel Antibody (B-6) Alexa Fluor® 546 | sc-6955 AF546 | 200 µg/ml | $364.00 | |||
c-Rel Antibody (B-6) Alexa Fluor® 594 | sc-6955 AF594 | 200 µg/ml | $364.00 | |||
c-Rel Antibody (B-6) Alexa Fluor® 647 | sc-6955 AF647 | 200 µg/ml | $364.00 | |||
c-Rel Antibody (B-6) Alexa Fluor® 680 | sc-6955 AF680 | 200 µg/ml | $364.00 | |||
c-Rel Antibody (B-6) Alexa Fluor® 790 | sc-6955 AF790 | 200 µg/ml | $364.00 |