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- mouse monoclonal IgA, 200 µg/ml
- specific for an epitope between amino acids 1095-1124 at the C-terminus of JAK3 of human origin
- recommended for detection of JAK3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- blocking peptide, sc-6932 P
- agarose conjugate for IP studies, sc-6932 AC, 500 µg/0.25 ml agarose
- HRP conjugate, sc-6932 HRP, 200 µg/ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
JAK3 |
3718 |
19p13.11 |
NM_000215 |
P52333
|
600173 |
| Mouse |
Jak3 |
16453 |
8 B3.3 |
|
Q62137
|
N/A |
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JAK3 Background Information
JAK3 (Janus kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
| JAK3 (B-12) Product Citations |
See how others have used JAK3 (B-12): sc-6932 antibody and or JAK3 (B-12) antibody conjugates.
4 total citations Loading citations.
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JAK3 (B-12)
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Western blot analysis of JAK3 expression in HeLa whole cell lysates (A,B). Antibodies tested include JAK3 (B-12): sc-6932 (A) and JAK3 (C-21): sc-513 (B). JAK3 (B-12): sc-6932. Western blot analysis of human recombinant JAK3 (A) and HeLa whole cell lysate (B).
JAK3 (B-12): sc-6932. Western blot analysis of JAK3 expression in non-transfected: sc-117752 (A) and truncated human JAK3 transfected: sc-114664 (B) 293T whole cell lysates. JAK3 (B-12): sc-6932. Western blot analysis of JAK3 expression in HuT 78 whole cell lysate.
JAK3 (B-12): sc-6932. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing nuclear localization.
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