epitope mapping at the N-terminus of PSD-95 of rat origin
recommended for detection of PSD-95 and PSD-93 of mouse, rat and human origin by WB, IF, IHC(P) and ELISA; also reactive with additional species, including bovine and porcine
PSD-95 Background Information The Drosophila discs large (dlg) tumor suppressor gene was first identified in Drosophila through genetic analysis of germline mutations (1). Several mammalian homologs were subsequently identified and categorized into a protein family termed MAGUK (membrane-associated guanylate kinase homolog) (2). Human homologs of dlg include hdlg-1 (rat SAP 97) and NE-dlg (neuronal and endocrine dlg) (3-5). The rat synaptic protein PSD-95 (also designated SAP 90) also shares homology with these proteins (6). MAGUKs are localized at the membrane-cytoskeleton interface and contain several distinct domains which suggest a role for these proteins in intracellular signal transduction (7). Interaction of hdlg-1 and NE-dlg with the tumor suppresor protein APC suggest that MAGUK proteins may also play a role in regulation of growth (5,8).
PSD-95 (N-18) Product Citations
See how others have used PSD-95 (N-18): sc-6926 antibody and or PSD-95 (N-18) antibody conjugates.
