epitope mapping at the N-terminus of NE-dlg of human origin
recommended for detection of NE-dlg of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
NE-dlg Background Information The Drosophila discs large (dlg) tumor suppressor gene was first identified in Drosophila through genetic analysis of germline mutations (1). Several mammalian homologs were subsequently identified and categorized into a protein family termed MAGUK (membrane-associated guanylate kinase homolog) (2). Human homologs of dlg include hdlg-1 (rat SAP-97) and NE-dlg (neuronal and endocrine dlg) (3-5). The rat synaptic protein SAP90 (also designated PSD-95) also shares homology with these proteins (6). MAGUKs are localized at the membrane-cytoskeleton interface and contain several distinct domains which suggest a role for these proteins in intracellular signal transduction (7). Interaction of hdlg-1 and NE-dlg with the tumor suppresor protein APC suggest that MAGUK proteins may also play a role in regulation of growth (5,8).
NE-dlg (N-19)
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NE-dlg (N-19): sc-6925. Western blot analysis of NE-dlg expression in mouse (A) and rat (B) brain extracts.
