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karyopherin α1/6 Antibody (C-20): sc-6918

 |  Datasheet

(Based on data analysis)

  • karyopherin α1/6 Antibody (C-20) is a goat polyclonal IgG provided at 200 µg/ml
  • raised against a peptide mapping at the C-terminus of karyopherin α1 of human origin
  • recommended for detection of karyopherin α1 and karyopherin α6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-6918 P
  • See 5 citations for karyopherin α1/6 Antibody (C-20)
 

See additional karyopherin Antibodies including karyopherin, karyopherin α3, karyopherin α7, karyopherin alpha 1, karyopherin beta 1, karyopherin alpha 2, karyopherin beta 2, karyopherin beta 2B, karyopherin beta 3, karyopherin alpha 5 , karyopherin alpha 6 and karyopherin 13.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
karyopherin α1/6 Antibody (C-20) sc-6918 200 µg/ml $279
karyopherin α1/6 (C-20) P sc-6918 P
(peptide)
 100 µg/0.5 ml $61
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
karyopherin α1 (h): 293T Lysate sc-111624 100 µg/200 µl $205
karyopherin α1 (m): 293T Lysate sc-121176 100 µg/200 µl $205
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
karyopherin α6 (h): 293 Lysate sc-113217 100 µg/200 µl $205
karyopherin α6 (m): 293T Lysate sc-125516 100 µg/200 µl $205
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human KPNA1 3836 3q21.1 NM_002264 P52294
 600686
Human KPNA6 23633 1p35.1 O60684
 610563
Mouse Kpna1 16646 16 B3 Q60960
 N/A
Mouse Kpna6 16650 4 D2.2 O35345
 N/A
 

Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors that mediate protein passage through the nuclear pore complex (NPC). Cytoplasmic proteins that contain nuclear localization signals (NLSs) must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Karyopherin å1 and karyopherin å6 are widely expressed nuclear import proteins that act as adaptors for karyopherin ∫1, specifically binding to and guiding NLS-containing proteins to the NPC. Both karyopherin å1 and karyopherin å6 contain one IBB domain and ten ARM repeats through which they convey their protein binding and localization function. Together, karyopherin å1 and karyopherin å6 are responsible for ensuring the nuclear import of NLS-containing substrates.

karyopherin α1/6 Antibody (C-20) Product Citations
See how others have used karyopherin α1/6 Antibody (C-20) and or karyopherin α1/6 Antibody (C-20) conjugates.


5 total citations
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karyopherin α1/6 Antibody (C-20) Data
Click on image to enlarge
sc-6918
karyopherin α1/6 (C-20): sc-6918. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse liver tissue showing perinuclear localization.
sc-6918
karyopherin α1/6 (C-20): sc-6918. Western blot analysis of karyopherin α6 expression in non-transfected: sc-110760 (A) and human karyopherin α6 transfected: sc-113217 (B) 293 whole cell lysates.
sc-6918
karyopherin α1/6 (C-20): sc-6918. Western blot analysis of karyopherin α1/6 expression in HeLa whole cell lysate.
sc-6918
karyopherin α1/6 (C-20): sc-6918. Western blot analysis of karyopherin α1 expression in non-transfected: sc-117752 (A) and human karyopherin α1 transfected: sc-111624 (B) 293T whole cell lysates.
sc-6918
karyopherin α1/6 (C-20): sc-6918. Western blot analysis of karyopherin α1 expression in non-transfected: sc-117752 (A) and mouse karyopherin α1 transfected: sc-121176 (B) 293T whole cell lysates.
sc-6918
karyopherin α1/6 (C-20): sc-6918. Western blot analysis of karyopherin α6 expression in non-transfected: sc-117752 (A) and mouse karyopherin α6 transfected: sc-125516 (B) 293T whole cell lysates.
sc-6918
karyopherin α1/6 (C-20): sc-6918. Western blot analysis of karyopherin α6 expression in non-transfected: sc-117752 (A) and human karyopherin α6 transfected: sc-173792 (B) 293T whole cell lysates.
sc-6918
karyopherin α1/6 (C-20): sc-6918. Western blot analysis of karyopherin α1 expression in non-transfected: sc-110760 (A) and human karyopherin α1 transfected: sc-171440 (B) 293 whole cell lysates.
sc-6918
karyopherin α1/6 (C-20): sc-6918. Immunoperoxidase staining of formalin fixed, paraffin-embedded human oral mucosa tissue showing cytoplasmic and nuclear staining of squamous epithelial cells.
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