Welcome to Santa Cruz Biotechnology!

Wip1 Antibody (C-18): sc-69130

 |  Datasheet

(Based on data analysis)

  • Wip1 Antibody (C-18) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of Wip1 of human origin
  • recommended for detection of Wip1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine
  • blocking peptide, sc-69130 P
 

See additional Wip1 Antibodies including Wip1 and Wip1.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 Antibody (C-18) sc-69130 200 µg/ml $279
Wip1 (C-18) P sc-69130 P
(peptide)
100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 siRNA (h) sc-39205 10 µM $258
Wip1 siRNA (m) sc-39206 10 µM $258
Wip1 (h)-PR sc-39205-PR 10 µM, 20 µl $23
Wip1 (m)-PR sc-39206-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 shRNA Plasmid (h) sc-39205-SH 20 µg $520
Wip1 shRNA Plasmid (m) sc-39206-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 shRNA (h) Lentiviral Particles sc-39205-V 200 µl $625
Wip1 shRNA (m) Lentiviral Particles sc-39206-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
F9 Cell Lysate sc-2245 500 µg/200 µl $104
Wip1 (h): 293 Lysate sc-113282 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PPM1D 8493 17q23.2 O15297
605100
 


Several major serine/threonine protein phosphatases have been identified in eukaryotic cells. These include protein phosphatase families 1, 2A, 2B, 2C, X and Y (PP-1, PP-2A, PP-2B, PP-2C, PP-X and PP-Y). These enzymes can be distinguished by their action on phosphorylase kinase and their sensitivity to certain activators and inhibitors. Wip1 (wildtype p53-induced phosphatase or PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP-2C family. Wip1 is a serine/threonine protein phosphatase which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53. Wip1 is ubiquitously expressed but is present at very high levels in testis. Deletion of Wip1 results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development.