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Wip1 Antibody (C-18): sc-69130

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  • Wip1 Antibody (C-18) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of Wip1 of human origin
  • recommended for detection of Wip1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine
  • blocking peptide, sc-69130 P

Monos, satisfaction guaranteed

Wip1 (C-18) will be discontinued December 31, 2016; to receive a 10 µg sample of Wip1 (F-10): sc-376257, our highly recommended and much superior monoclonal antibody alternative to this product, please contact Technical Service.

 

See additional Wip1 Antibodies including Wip1 and Wip1.

Also see chemical Wip1 Inhibitors for functional analysis of cellular responses to Wip1.


Ordering InformationGene Info
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 (C-18) P sc-69130 P
(peptide)
100 µg/0.5 ml $61
Wip1 Antibody (C-18) sc-69130 200 µg/ml $279
 CRISPR KO, HDR and Nickase Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 CRISPR/Cas9 KO Plasmid (h) sc-400980 20 µg $345
Wip1 HDR Plasmid (h) sc-400980-HDR 20 µg $385
Wip1 Double Nickase Plasmid (h) sc-400980-NIC 20 µg $355
Wip1 Double Nickase Plasmid (h2) sc-400980-NIC-2 20 µg $355
Wip1 CRISPR/Cas9 KO Plasmid (m) sc-424767 20 µg $345
Wip1 HDR Plasmid (m) sc-424767-HDR 20 µg $385
Wip1 Double Nickase Plasmid (m) sc-424767-NIC 20 µg $355
Wip1 Double Nickase Plasmid (m2) sc-424767-NIC-2 20 µg $355
 CRISPR Activation Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 CRISPR Activation Plasmid (h) sc-400980-ACT 20 µg $345
Wip1 CRISPR Activation Plasmid (h2) sc-400980-ACT-2 20 µg $345
Wip1 Lentiviral Activation Particles (h) sc-400980-LAC 200 µl $395
Wip1 Lentiviral Activation Particles (h2) sc-400980-LAC-2 200 µl $395
Wip1 CRISPR Activation Plasmid (m) sc-424767-ACT 20 µg $345
Wip1 CRISPR Activation Plasmid (m2) sc-424767-ACT-2 20 µg $345
Wip1 Lentiviral Activation Particles (m) sc-424767-LAC 200 µl $395
Wip1 Lentiviral Activation Particles (m2) sc-424767-LAC-2 200 µl $395
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 siRNA (h) sc-39205 10 µM $258
Wip1 siRNA (m) sc-39206 10 µM $258
Wip1 (h)-PR sc-39205-PR 10 µM, 20 µl $23
Wip1 (m)-PR sc-39206-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 shRNA Plasmid (h) sc-39205-SH 20 µg $520
Wip1 shRNA Plasmid (m) sc-39206-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Wip1 shRNA (h) Lentiviral Particles sc-39205-V 200 µl $625
Wip1 shRNA (m) Lentiviral Particles sc-39206-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
F9 Cell Lysate sc-2245 500 µg/200 µl $104
Wip1 (h): 293 Lysate sc-113282 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PPM1D 8493 17q22 NM_003620 O15297
605100
 


Several major serine/threonine protein phosphatases have been identified in eukaryotic cells. These include protein phosphatase families 1, 2A, 2B, 2C, X and Y (PP-1, PP-2A, PP-2B, PP-2C, PP-X and PP-Y). These enzymes can be distinguished by their action on phosphorylase kinase and their sensitivity to certain activators and inhibitors. Wip1 (wildtype p53-induced phosphatase or PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP-2C family. Wip1 is a serine/threonine protein phosphatase which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53. Wip1 is ubiquitously expressed but is present at very high levels in testis. Deletion of Wip1 results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development.

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