epitope corresponding to amino acids 21-320 mapping near the N-terminus of CSMD3 of human origin
recommended for detection of CSMD1, CSMD2 and CSMD3 of human origin, and CSMD1 and CSMD3 of mouse and rat origin by WB, IP, IF and ELISA; non cross-reactive with CSMD2 of mouse and rat origin; also reactive with additional species, including equine, canine and avian
CSMD1/2/3 Background Information The CUB and sushi domain-containing proteins, CSMD1-3, are membrane proteins that are involved in cell-cell adhesion and are weakly expressed in most tissues, with higher levels of expression observed in the cerebellum and hippocampus. CSMD1 is part of the complement system that defends against pathogens through either the classical pathway or the alternative pathway. Located primarily in nerve growth cones, CSMD1 blocks the classical pathway of the immune system and is thought to be involved in tumor suppression, as defects in the gene encoding CSMD1 are associated with squamous cell carcinomas. CSMD2 and CSMD3 are located primarily in the brain and are implicated in some forms of head and neck cancer. Additionally, the CSMD3 gene is a candidate for induction of epileptic seizures.
