NALP13 Background Information
NALPs (NACHT-, LRR- and PYD-containing proteins) comprise a subfamily of caterpiller proteins and function in the regulation of apoptosis and signaling pathways. Short NALP proteins contain an N-terminal pyrin domain, as well as a NACHT domain, a NACHT-associated domain (NAD) and a C-terminal leucine-rich repeat (LRR) region, while long NALP proteins exhibit a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALP13, also known as NLRP13 (NLR family, pyrin domain containing 13), NOD14 or PAN13, is a 1,043 amino acid member of the NALP protein family and exists as a short NALP, containing one DAPIN domain, one NACHT domain and 7 LRR repeats. Characteristic of NALP proteins, NALP13 functions as a component of inflammasomes and is involved in inflammatory responses throughout the body.
