epitope corresponding to amino acids 465-610 mapping near the N-terminus of MACF1, isoform 1 of human origin
recommended for detection of MACF1, isoforms 1/2/3/5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
MACF1 Background Information MACF1 (Microtubule-actin cross-linking factor 1) is a 5,327 amino acid protein that is encoded by the human gene MACF1. MACF1 belongs to the plakin or cytolinker family and contains one actin-binding domain, two CH (calponin-homology) domains, two EF-hand domains, one SH3 domain and thirty-seven spectrin repeats. MACF1 is an F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. The spectrin repeats, an important feature found in many proteins involved in cytoskeletal structure, forms a three helix bundle with the second helix (with proline interrupts in some sequences). MACF1 is a cytoplasmic protein expressed mainly in lung, brain, spinal cord, skeletal and cardiac muscle, and skin.
MACF1 (H-146) Product Citations
See how others have used MACF1 (H-146): sc-68428 antibody and or MACF1 (H-146) antibody conjugates.
