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ADAMTS-18 Antibody (H-155): sc-68416

 |  Datasheet

(Based on data analysis)

  • ADAMTS-18 Antibody (H-155) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 986-1140 mapping near the C-terminus of ADAMTS-18 of human origin
  • recommended for detection of ADAMTS-18 of mouse, rat and human origin by WB, IP, IF and ELISA
 
Full-length ADAMTS-18 protein sequence with immunogen highlighted:
MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI

See additional ADAMTS Antibodies including ADAMTS, ADAMTS-1, ADAMTS-2, ADAMTS-L2, ADAMTS-3, ADAMTS-4, ADAMTS-L4, ADAMTS-L5, ADAMTS-5, ADAMTS-6, ADAMTS-7, ADAMTS-8, ADAMTS-9, ADAMTS-10, ADAMTS-12, ADAMTS-13, ADAMTS-14, ADAMTS-15, ADAMTS-16, ADAMTS-17, ADAMTS-18, ADAMTS-19 and ADAMTS-20.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
ADAMTS-18 Antibody (H-155) sc-68416 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ADAMTS-18 siRNA (h) sc-61954 10 µM $258
ADAMTS-18 siRNA (m) sc-61955 10 µM $258
ADAMTS-18 (h)-PR sc-61954-PR 10 µM, 20 µl $23
ADAMTS-18 (m)-PR sc-61955-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ADAMTS-18 shRNA Plasmid (h) sc-61954-SH 20 µg $520
ADAMTS-18 shRNA Plasmid (m) sc-61955-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ADAMTS-18 shRNA (h) Lentiviral Particles sc-61954-V 200 µl $625
ADAMTS-18 shRNA (m) Lentiviral Particles sc-61955-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ECV304 Cell Lysate sc-2269 500 µg/200 µl $104
PC-3 Cell Lysate sc-2220 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ADAMTS18 170692 16q23.1 NM_139054, NM_199355 Q8TE60
607512
Mouse Adamts18 208936 8 E1 Q4VC17
N/A
 


ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of thrombospondin 1 (TSP 1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. ADAMTS-18 is a secreted protein that is also expressed in adult brain, endothelium, prostate and submaxillary gland. ADAMTS-18 has two known splice variants and it is structurally most similar to ADAMTS-16. ADAMTS-18 is downregulated in carcinoma cell lines by methylation of its promoter. Forced expression of ADAMTS-18 in carcinoma cells can lead to significant inhibition of cell growth, suggesting that it plays a significant role as a tumor suppressor.