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Endo180 Antibody (C-17): sc-68075

 |  Datasheet

(Based on data analysis)
  • Endo180 Antibody (C-17) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within a C-terminal extracellular domain of Endo180 of human origin
  • recommended for detection of endocytic receptor 180 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-68075 P
 

See additional Endo180 Antibodies.

Ordering InformationGene Info
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Endo180 Antibody (C-17) sc-68075 200 µg/ml $279
Endo180 (C-17) P sc-68075 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Endo180 siRNA (h) sc-62276 10 µM $258
Endo180 siRNA (m) sc-62277 10 µM $258
Endo180 (h)-PR sc-62276-PR 10 µM, 20 µl $23
Endo180 (m)-PR sc-62277-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Endo180 shRNA Plasmid (h) sc-62276-SH 20 µg $520
Endo180 shRNA Plasmid (m) sc-62277-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Endo180 shRNA (h) Lentiviral Particles sc-62276-V 200 µl $625
Endo180 shRNA (m) Lentiviral Particles sc-62277-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MRC2 9902 17q23.2 NM_006039 Q9UBG0
 n/a
Mouse Mrc2 17534 11 E1 Q64449
 N/A
 

Endo180 (Endocytic receptor 180), also known as macrophage mannose receptor C type 2 (MRC2), urokinase plasminogen activator receptor-associated protein (uPARAP) or CD280 antigen, is a ubiquitously expressed, type I membrane protein with predominant expression in fetal lung and kidney. The extracellular domain of Endo180 contains a fibronectin type II domain, eight C-type lectin domains and a cysteine-rich domain. Endo180 functions as a cell surface receptor and mediates collagen matrix remodeling as well as cell migration by playing a role in the uptake and lysosomal degradation of collagen. Endo180 can bind to gelatin and collagens I, II, IV and V. It may play a role in wound regeneration. In addition, Endo180 can form a complex with uPAR and pro-uPA, thereby partaking in a variety of cellular proteolytic and signaling functions. Endo180 participates in the destruction of connective tissue during the progression of head and neck squamous cell carcinoma.