Peroxin 6 Antibody (A-15): sc-67749

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Peroxisomes are single-membrane bound organelles present in virtually all eukaryotic cells. They are involved in numerous catabolic and anabolic pathways, including ∫-oxidation of very long chain fatty acids, metabolism of hydrogen peroxide, plasmalogen biosynthesis and bile acid synthesis. The Peroxin gene family, which includes more than 20 members, is required for peroxisome biogenesis. One such member of the Peroxin gene family is Peroxin 6. Of 11 mutations identified in the gene Pex6, most led to premature termination or large deletions of the Peroxin 6 protein and resulted in the most severe peroxisome biogenesis disorder phenotype of Zellweger syndrome, a disorder associated with major deformations.