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home » Cell Cycle Proteins » ZWINT Antibody / ZWINT Antibodies » ZWINT (FL-277): sc-67363

ZWINT (FL-277) Antibody: sc-67363

  |  Datasheet
  • rabbit polyclonal IgG, 200µg/ml
  • epitope corresponding to amino acids 1-277 (deletion 228-229) representing full length ZWINT of human origin
  • recommended for detection of ZWINT of human and, to a lesser extent, mouse and rat origin by WB, IP, IF, IHC(P) and ELISA
 
Additional ZWINT Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ZWINT 11130 10q21.1 NM_001005413, NM_001005414, NM_007057, NM_032997 O95229
 609177
Mouse Zwint 52696 10 B5.3 NM_025635 Q9CQU5
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
ZWINT (FL-277) sc-67363 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ZWINT siRNA (h) sc-63263 10 µM $258
ZWINT siRNA (m) sc-63264 10 µM $258
ZWINT (h)-PR sc-63263-PR 10 µM $23
ZWINT (m)-PR sc-63264-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ZWINT shRNA Plasmid (h) sc-63263-SH 20 µg $520
ZWINT shRNA Plasmid (m) sc-63264-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ZWINT shRNA (h) Lentiviral Particles sc-63263-V 200 µl $625
ZWINT shRNA (m) Lentiviral Particles sc-63264-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa nuclear extract sc-2120 1000 µg $143
ZWINT (h2): 293 Lysate sc-112895 100µg/200µl $205
ZWINT (h): 293T Lysate sc-112460 100µg/200µl $205
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

ZWINT Background Information
ZWINT (ZW10 interactor), also known as KNTC2AP or HZwint-1, is a 277 amino acid protein that is involved in kinetochore function. Localized to the cytoplasm during interphase and to kinetochores from late prophase to anaphase, ZWINT interacts with ZW10 (Zeste White 10) and functions to regulate the association between ZW10 and kinetochores. Additionally, ZWINT is part of a kinetochore complex composed of proteins such as MIS12 (MIND kinetochore complex component) and PMF-1 (polyamine-modulated factor 1) that work in concert to ensure proper kinetochore formation and spindle checkpoint activity. Defects in the gene encoding ZWINT are associated with the pathogenesis of Roberts syndrome, an autosomal recessive disorder characterized by growth retardation due to premature chromosome separation.
ZWINT (FL-277)
Click on image to enlarge
sc-67363
ZWINT (FL-277): sc-67363. Western blot analysis of ZWINT expression in non-transfected: sc-110760 (A) and human ZWINT transfected: sc-112895 (B) 293 whole cell lysates.
sc-67363
ZWINT (FL-277): sc-67363. Western blot analysis of ZWINT expression in non-transfected 293T: sc-117752 (A), human ZWINT transfected 293T: sc-112460 (B) and A-431 (C) whole cell lysates.
sc-67363
ZWINT (FL-277): sc-67363. Western blot analysis of ZWINT expression in non-transfected: sc-117752 (A) and mouse ZWINT transfected: sc-124836 (B) 293T whole cell lysates.
sc-67363
ZWINT (FL-277): sc-67363. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis showing nuclear staining of cells in seminiferus ducts at high magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
sc-67363
ZWINT (FL-277): sc-67363. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis showing nuclear staining of cells in seminiferus ducts at low magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
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