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ATMIN Antibody (H-243): sc-67314

 |  Datasheet

(Based on data analysis)
  • ATMIN Antibody (H-243) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 581-823 mapping at the C-terminus of ATMIN of human origin
  • recommended for detection of ATMIN of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and bovine
 
Full-length ATMIN protein sequence with immunogen highlighted:
MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPRGPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIEKSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQNPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF

See additional ATMIN Antibodies.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
ATMIN Antibody (H-243) sc-67314 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ATMIN siRNA (h) sc-105098 10 µM $258
ATMIN siRNA (m) sc-141330 10 µM $258
ATMIN (h)-PR sc-105098-PR 10 µM, 20 µl $23
ATMIN (m)-PR sc-141330-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ATMIN shRNA Plasmid (h) sc-105098-SH 20 µg $520
ATMIN shRNA Plasmid (m) sc-141330-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ATMIN shRNA (h) Lentiviral Particles sc-105098-V 200 µl $625
ATMIN shRNA (m) Lentiviral Particles sc-141330-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
JAR Cell Lysate sc-2276 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ATMIN 23300 16q23.2 NM_015251 O43313
 n/a
Mouse Atmin 234776 8 E1 Q6P9S1
 N/A
 

ATMIN (ATM/ATR-substrate Chk2-interacting Zn2+-finger protein) is a DNA damage response protein. It functions as a scaffold protein in the lesion-specific Rad51 focus forming pathway. In response to DNA methylating agents and persistent single stranded DNA gaps, ATMIN forms Rad51-containing foci for DNA repair. The ATMIN foci are MLH1-dependent. ATMIN is similar in structure and function to Mdt1. It consists of an N-terminal nucleic acid binding domain, a nuclear localization signal and a C-terminal SQ/TQ cluster domain (SCD). ATMIN interacts with the Forkhead-associated (FHA) domain of Chk2 via its SCD and may be a substrate for ATM/ATR kinase. A lack in functional ATMIN results in impaired Rad51 focus formation and leads to increased DNA damage-induced apoptosis.