GM2/GD2 Synthase Background Information GM2/GD2 synthase is a 533 amino acid protein encoded by the human gene B4GALNT1. The GM2 and GD2 gangliosides are sialic acid-containing glyco-sphingolipids that play a role in signal transduction and cell-cell recognition. GM2/GD2 synthase is expressed abundantly in normal brain tissue of vertebrates. It contains a single 18 amino acid hydrophobic segment near the amino-terminus flanked by basic residues. GM2/GD2 synthase primarily controls the balance between expression of simple and complex gangliosides at the cell surface. The ganglioside GD2 is expressed using GM2/GD2 synthase in almost all neuroblastomas (NBs) as well as other neuroectoderm-derived tumor cells, such as malignant melanoma, adult T cell leukemia and some colon and gastric cancers. GM2/GD2 synthase is a useful marker for NBs, and may aid in evaluating adjuvant treatment efficacy in neuroblastoma with prognostic potential.
GM2/GD2 Synthase (M-180)
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GM2/GD2 Synthase (M-180): sc-67311. Western blot analysis of GM2 Synthase and GD2 Synthase expression in non-transfected: sc-117752 (A) and human GM2/GD2 Synthase transfected: sc-114482 (B) 293T whole cell lysates.
GM2/GD2 Synthase (M-180): sc-67311. Western blot analysis of GM2/GD2 Synthase expression in non-transfected 293T: sc-117752 (A), mouse GM2/GD2 Synthase transfected 293T: sc-120535 (B) and HeLa (C) whole cell lysates.
GM2/GD2 Synthase (M-180): sc-67311. Western blot analysis of GM2/GD2 Synthase expression in HeLa whole cell lysate.
