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NDR1/2 (H-100) Antibody: sc-66998 |
| Datasheet |
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- rabbit polyclonal IgG, 200µg/ml
- epitope corresponding to amino acids 1-100 mapping at the N-terminus of NDR1 of human origin
- recommended for detection of NDR1 and NDR2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
STK38 |
11329 |
6p21.31 |
NM_007271 |
Q15208
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606964 |
| Mouse |
Stk38 |
106504 |
17 A3.3 |
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Q91VJ4
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N/A |
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NDR1/2 Background Information
The nuclear Dbf2-related kinases (NDR1 and NDR2) participate in the regulation of cell division and morphology and may be implicated in tumor progression. NDR1 and NDR2 share 86% amino acid identity, but differ in their expression pattern. NDR1 localizes to the nucleus, while NDR2 exhibits punctate cytoplasmic distribution. Also, NDR1 expression appears highest in spleen, lung and thymus, whereas NDR2 shows highest expression in the gastrointestinal tract. However, both NDR1 and NDR2 are regulated by phosphorylation and by the Ca2+-binding protein S-100B. NDR1 and NDR2 may also play a role in the HIV-1 life cycle. Both proteins are cleaved by the HIV-1 protease (PR), which inhibits their enzymatic activity and alters the subcellular localization of NDR2. The genes encoding human NDR1 and NDR2 map to chromosomes 6p21 and 12p11.23, respectively.
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NDR1/2 (H-100)
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NDR1/2 (H-100): sc-66998. Western blot analysis of NDR1 expression in non-transfected: sc-117752 (A) and mouse NDR1 transfected: sc-121961 (B) 293T whole cell lysates. NDR1/2 (H-100): sc-66998. Western blot analysis of NDR1/2 expression in Jurkat nuclear extract.
NDR1/2 (H-100): sc-66998. Western blot analysis of NDR1/2 expression in HeLa whole cell lysate.
NDR1/2 (H-100): sc-66998. Western blot analysis of NDR1/2 expression in NIH/3T3 (A), PC-12 (B) and RAW 264.7 (C) whole cell lysates and mouse liver (D) and mouse kidney (E) tissue extracts.
NDR1/2 (H-100): sc-66998. Western blot analysis of NDR1/2 expression in U-937 (A) and HEL 92.1.7 (B) nuclear extracts and human PBL whole cell lysate (C).
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