ZWINT Background Information ZWINT (ZW10 interactor), also known as KNTC2AP or HZwint-1, is a 277 amino acid protein that is involved in kinetochore function. Localized to the cytoplasm during interphase and to kinetochores from late prophase to anaphase, ZWINT interacts with ZW10 (Zeste White 10) and functions to regulate the association between ZW10 and kinetochores. Additionally, ZWINT is part of a kinetochore complex composed of proteins such as MIS12 (MIND kinetochore complex component) and PMF-1 (polyamine-modulated factor 1) that work in concert to ensure proper kinetochore formation and spindle checkpoint activity. Defects in the gene encoding ZWINT are associated with the pathogenesis of Roberts syndrome, an autosomal recessive disorder characterized by growth retardation due to premature chromosome separation.
ZWINT (P-19)
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ZWINT (P-19): sc-66701. Western blot analysis of ZWINT expression in PC-12 whole cell lysate (A) and rat brain tissue extract (B).
