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gremlin-2 Antibody (D-15): sc-66533

 |  Datasheet

(Based on data analysis)
  • gremlin-2 Antibody (D-15) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of gremlin-2 of human origin
  • recommended for detection of gremlin-2 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine and canine
  • blocking peptide, sc-66533 P
 

See additional gremlin Antibodies including gremlin-2, gremlin-1 and gremlin.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
gremlin-2 Antibody (D-15) sc-66533 200 µg/ml $279
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GREM2 64388 1q43 NM_022469 Q9H772
 608832
Mouse Grem2 23893 1 H3 NM_011825 O88273
 N/A
 

The gremlin protein family contains antagonists of bone morphogenetic protein (BMP) signaling that are expressed in the neural crest. All family members are secreted proteins that act as BMP antagonists in embryonic explants and are expressed in the proximal airway epithelium of the lung during embryonic development. Gremlin-1 is required for early limb outgrowth and patterning in the FGF4-SHH feedback loop, while gremlin-2 binds and blocks the activity of BMP-2 and BMP-4. The dorsaling factor gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN. Additionally, secreted gremlin relays the sonic hedgehog signal from the polarizing region to the apical ectodermal ridge.