Ada2 Background Information Chromatin remodeling, thought to be a critical component of transcriptional regulation, is effected by the acetylation of nucleosomal histones. Acetylation results in an allosteric change in the nucleosomal conformation and an increased accessibility of DNA to transcription factors. Conversely, the deacetylation of histones is associated with transcriptional silencing. Gon5 (also designated Ada4) has been identified as a yeast histone acetylase. This protein forms a complex with Ada2 and Ada3 (also designated Ngg1), which facilitate transcriptional activation. Rpd3 (also designated Sdi2) and Hda1 have been identified as histone deacetylases. Sin3 (also designated Rpd1, Gam2, Ume4 or Sdi1) is involved in the transcriptional repression of many genes. This protein binds to Rpd3 and is thought to function by recruiting Rpd3 to specific promoters.
