p-Troponin I-C Antibody (1G11): sc-66159

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Actin and Myosin are highly conserved proteins that are expressed in all eukaryotic cells. Actin filaments are crucial components of the contractile apparatus of muscle cells. Myosins interact with Actin to generate the force for diverse cellular movements. Troponin facilitates the interactions between actin and myosin by binding to Ca2+. Troponin contains three subunits, Troponin C, I and T. Troponin C, the Ca2+ binding subunit, is expressed in cardiac and slow skeletal muscle, and is involved in regulating the excitation-contraction coupling in cardiac muscle. Troponin I, the inhibitory subunit of Troponin, exists as fast and slow skeletal muscle isoforms, which are differentially expressed in individual muscle fibers, and cardiac as Troponin I, which is exclusively expressed in cardiac muscle. Troponin T, the tropomyosin-binding subunit of Troponin, plays a role in conferring calcium-sensitivity to actomyosin ATPase activity, and it exists as fast and slow skeletal and cardiac isoforms.