Rab 25 (3F12F3) Antibody: sc-65978

Rab 25 Background Information
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 25, also known as CATX-8 or Rab 11c, is a member of the Rab family of proteins that is exclusively expressed in epithelial cells and participates in apical vesicle trafficking. Rab 25 is overexpressed in ovarian and breast cancer cells and has been associated with metastasis and tumor aggressiveness. The forced expression of Rab 25 in ovarian and breast cancer cells increases cell proliferation in vivo.