Date published: 2026-8-13

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HNF Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of HNF Antibodies for research focused on understanding hepatocyte nuclear factors. HNF Antibodies are compatible with multiple techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Hepatocyte nuclear factors are transcription factors that play key roles in regulating glucose metabolism, insulin secretion, and liver function. Maintaining proper metabolic homeostasis depends on hepatocyte nuclear factor activity, and disruptions can result in diabetes and liver diseases. Understanding HNF regulation and function provides insights into metabolic disorders and potential treatments. Research into hepatocyte nuclear factors continues to reveal new aspects of metabolic pathway regulation. Investigating HNF expression patterns helps identify biomarkers for early disease detection. Exploring HNF signaling networks advances knowledge of cellular metabolism and tissue development. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific understanding of metabolic diseases and potential therapeutic approaches.

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HNF Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

HNF-1α Antibody (F-7)

sc-393925mouse IgG2a κ80-284 (h)WB, IP, IF, ELISAm, r, h
12
(8)

HNF-1α Antibody (2)

sc-135939mouse IgG170-269 (m)WB, IP, IFm, r, h
6
(3)

HNF-1α Antibody (B-3)

sc-393668mouse IgG1 κ618-631 (h)WB, IP, IF, ELISAm, r, h
5
(1)

HNF-1β Antibody (94.8)

sc-130407mouse IgG2a κ29-118 (h)WB, IPh
5
(2)

HNF-3α Antibody (A-3)

sc-514695mouse IgG2a κ51-170 (h)WB, IP, IF, ELISAm, r, h
10
(6)

HNF-3α Antibody (Q-6)

sc-101058mouse IgG2a κ367-473 (h)WB, IP, IF, IHC(P), ELISAm, r, h
34
(8)

HNF-3α/β Antibody (E-4)

sc-377033mouse IgG1 κ445-473 (h)WB, IP, IF, IHC(P), ELISAm, r, h
5
(2)

HNF-3β Antibody (H-4)

sc-374376mouse IgG1 κ431-459 (m)WB, IP, IF, ELISAm, r, h
56
(10)

HNF-3β Antibody (RY-7)

sc-101060mouse IgG2a κ363-458 (h)WB, IP, IF, IHC(P), ELISAm, r, h
60
(9)

HNF-3β Antibody (B-2)

sc-271103mouse IgG1 κ261-370 (h)WB, IP, IF, ELISAm, r, h
5
(4)

HNF-3β Antibody (H-8)

sc-271104mouse IgG2b κ261-370 (h)WB, IP, IF, ELISAm, r, h
1
(2)

HNF-3β Antibody (A-12)

sc-374375mouse IgG1 κ431-459 (m)WB, IP, IF, ELISAm, r, h
6
(4)

HNF-3γ Antibody (A-2)

sc-74424mouse IgG1 κ1-115 (h)WB, IP, IF, ELISAm, r, h
6
(4)

HNF-3γ Antibody (D-4)

sc-166703mouse IgG1 κN-terminal (h)WB, IP, IF, ELISAm, r, h
1
(2)

HNF-3γ Antibody (G-2)

sc-271229mouse IgG2a κ8-40 (h)WB, IP, IF, ELISAm, r, h

new

(1)

HNF-4α Antibody (H-1)

sc-374229mouse IgG1 κ295-465 (h)WB, IP, IF, IHC(P), ELISAm, r, h
61
(15)

HNF-4α Antibody (Q-15)

sc-101059mouse IgG2a κ324-424 (h)WB, IP, IF, ELISAm, r, h
3
(3)

HNF-6 Antibody (G-10)

sc-376167mouse IgG1 κ11-110 (h)WB, IP, IF, ELISAm, r, h
6
(3)

HNF-6 Antibody (B-1)

sc-376308mouse IgG2b κ11-110 (h)WB, IP, IF, ELISAm, r, h
4
(1)

HNF siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

HNF-1α siRNA (h)

sc-35567hGene SilencingN/A
6
(0)

HNF-1α shRNA Plasmid (h)

sc-35567-SHhGene SilencingPuromycin
6
(0)

HNF-1α shRNA (h) Lentiviral Particles

sc-35567-VhGene SilencingPuromycin
6
(0)

HNF-1α siRNA (m)

sc-35568mGene SilencingN/A
3
(0)

HNF-1α shRNA Plasmid (m)

sc-35568-SHmGene SilencingPuromycin
3
(0)

HNF-1α shRNA (m) Lentiviral Particles

sc-35568-VmGene SilencingPuromycin
3
(0)

HNF-1β siRNA (h)

sc-37928hGene SilencingN/A
2
(0)

HNF-1β siRNA (h2)

sc-43839hGene SilencingN/A0
(0)

HNF-1β shRNA Plasmid (h)

sc-37928-SHhGene SilencingPuromycin
2
(0)

HNF-1β shRNA Plasmid (h2)

sc-43839-SHhGene SilencingPuromycin0
(0)

HNF-1β shRNA (h) Lentiviral Particles

sc-37928-VhGene SilencingPuromycin
2
(0)

HNF-1β shRNA (h2) Lentiviral Particles

sc-43839-VhGene SilencingPuromycin0
(0)

HNF-1β siRNA (m)

sc-37929mGene SilencingN/A
1
(0)

HNF-1β shRNA Plasmid (m)

sc-37929-SHmGene SilencingPuromycin
1
(0)

HNF-1β shRNA (m) Lentiviral Particles

sc-37929-VmGene SilencingPuromycin
1
(0)

HNF-3α siRNA (h)

sc-37930hGene SilencingN/A
10
(0)

HNF-3α shRNA Plasmid (h)

sc-37930-SHhGene SilencingPuromycin
10
(0)

HNF-3α shRNA (h) Lentiviral Particles

sc-37930-VhGene SilencingPuromycin
10
(0)

HNF-3α siRNA (m)

sc-37931mGene SilencingN/A
2
(0)

HNF-3α shRNA Plasmid (m)

sc-37931-SHmGene SilencingPuromycin
2
(0)

HNF-3α shRNA (m) Lentiviral Particles

sc-37931-VmGene SilencingPuromycin
2
(0)

HNF-3β siRNA (h)

sc-35569hGene SilencingN/A
14
(0)

HNF-3β shRNA Plasmid (h)

sc-35569-SHhGene SilencingPuromycin
14
(0)

HNF-3β shRNA (h) Lentiviral Particles

sc-35569-VhGene SilencingPuromycin
14
(0)

HNF-3β siRNA (m)

sc-35570mGene SilencingN/A
1
(0)

HNF-3β shRNA Plasmid (m)

sc-35570-SHmGene SilencingPuromycin
1
(0)

HNF-3β shRNA (m) Lentiviral Particles

sc-35570-VmGene SilencingPuromycin
1
(0)

HNF-3γ siRNA (h)

sc-35571hGene SilencingN/A0
(0)

HNF-3γ shRNA Plasmid (h)

sc-35571-SHhGene SilencingPuromycin0
(0)

HNF-3γ shRNA (h) Lentiviral Particles

sc-35571-VhGene SilencingPuromycin0
(0)

HNF-3γ siRNA (m)

sc-35572mGene SilencingN/A0
(0)

HNF-3γ shRNA Plasmid (m)

sc-35572-SHmGene SilencingPuromycin0
(0)

HNF-3γ shRNA (m) Lentiviral Particles

sc-35572-VmGene SilencingPuromycin0
(0)

HNF-4α siRNA (h)

sc-35573hGene SilencingN/A
8
(0)

HNF-4α shRNA Plasmid (h)

sc-35573-SHhGene SilencingPuromycin
8
(0)

HNF-4α shRNA (h) Lentiviral Particles

sc-35573-VhGene SilencingPuromycin
8
(0)

HNF-4α siRNA (m)

sc-35574mGene SilencingN/A0
(0)

HNF-4α shRNA Plasmid (m)

sc-35574-SHmGene SilencingPuromycin0
(0)

HNF-4α shRNA (m) Lentiviral Particles

sc-35574-VmGene SilencingPuromycin0
(0)

HNF-4γ/HNF4G siRNA (h)

sc-37934hGene SilencingN/A0
(0)

HNF-4γ/HNF4G shRNA Plasmid (h)

sc-37934-SHhGene SilencingPuromycin0
(0)

HNF-4γ/HNF4G shRNA (h) Lentiviral Particles

sc-37934-VhGene SilencingPuromycin0
(0)

HNF-4γ/HNF4G siRNA (m)

sc-37935mGene SilencingN/A0
(0)

HNF-4γ/HNF4G shRNA Plasmid (m)

sc-37935-SHmGene SilencingPuromycin0
(0)

HNF-4γ/HNF4G shRNA (m) Lentiviral Particles

sc-37935-VmGene SilencingPuromycin0
(0)

HNF-6 siRNA (h)

sc-37936hGene SilencingN/A0
(0)

HNF-6 shRNA Plasmid (h)

sc-37936-SHhGene SilencingPuromycin0
(0)

HNF-6 shRNA (h) Lentiviral Particles

sc-37936-VhGene SilencingPuromycin0
(0)

HNF-6 siRNA (m)

sc-37937mGene SilencingN/A0
(0)

HNF-6 shRNA Plasmid (m)

sc-37937-SHmGene SilencingPuromycin0
(0)

HNF-6 shRNA (m) Lentiviral Particles

sc-37937-VmGene SilencingPuromycin0
(0)

HNF CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

HNF-1β CRISPR/Cas9 KO Plasmid (h)

sc-400537Gene Knockouth0
(0)

HNF-1β HDR Plasmid (h)

sc-400537-HDRHomology Directed Repairh0
(0)

HNF-3α CRISPR/Cas9 KO Plasmid (h2)

sc-400743-KO-2Gene Knockouth0
(0)

HNF-3α HDR Plasmid (h2)

sc-400743-HDR-2Homology Directed Repairh0
(0)

HNF-3α CRISPR/Cas9 KO Plasmid (m)

sc-420889Gene Knockoutm0
(0)

HNF-3α HDR Plasmid (m)

sc-420889-HDRHomology Directed Repairm0
(0)

HNF-3β CRISPR/Cas9 KO Plasmid (h)

sc-400210Gene Knockouth0
(0)

HNF-3β HDR Plasmid (h)

sc-400210-HDRHomology Directed Repairh0
(0)

HNF-3β CRISPR/Cas9 KO Plasmid (m)

sc-420890Gene Knockoutm0
(0)

HNF-4α CRISPR/Cas9 KO Plasmid (h2)

sc-400159-KO-2Gene Knockouth0
(0)

HNF-4α HDR Plasmid (h2)

sc-400159-HDR-2Homology Directed Repairh0
(0)

HNF-4α CRISPR/Cas9 KO Plasmid (m)

sc-420892Gene Knockoutm0
(0)

HNF-4α HDR Plasmid (m)

sc-420892-HDRHomology Directed Repairm0
(0)

HNF-6 CRISPR/Cas9 KO Plasmid (h)

sc-401082Gene Knockouth0
(0)

HNF-6 CRISPR/Cas9 KO Plasmid (m)

sc-420893Gene Knockoutm0
(0)

HNF CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

HNF-1α Double Nickase Plasmid (h)

sc-400594-NICGene Knockouth0
(0)

HNF-1α Double Nickase Plasmid (h2)

sc-400594-NIC-2Gene Knockouth0
(0)

HNF-1β Double Nickase Plasmid (h)

sc-400537-NICGene Knockouth0
(0)

HNF-1β Double Nickase Plasmid (h2)

sc-400537-NIC-2Gene Knockouth0
(0)

HNF-1β Double Nickase Plasmid (m)

sc-423295-NICGene Knockoutm0
(0)

HNF-1β Double Nickase Plasmid (m2)

sc-423295-NIC-2Gene Knockoutm0
(0)

HNF-3α Double Nickase Plasmid (h)

sc-400743-NICGene Knockouth0
(0)

HNF-3α Double Nickase Plasmid (h2)

sc-400743-NIC-2Gene Knockouth0
(0)

HNF-3β Double Nickase Plasmid (h)

sc-400210-NICGene Knockouth0
(0)

HNF-3β Double Nickase Plasmid (h2)

sc-400210-NIC-2Gene Knockouth0
(0)

HNF-3γ Double Nickase Plasmid (h)

sc-401720-NICGene Knockouth0
(0)

HNF-3γ Double Nickase Plasmid (h2)

sc-401720-NIC-2Gene Knockouth0
(0)

HNF-4α Double Nickase Plasmid (h)

sc-400159-NICGene Knockouth0
(0)

HNF-4α Double Nickase Plasmid (h2)

sc-400159-NIC-2Gene Knockouth0
(0)

HNF-6 Double Nickase Plasmid (h)

sc-401082-NICGene Knockouth0
(0)

HNF-6 Double Nickase Plasmid (h2)

sc-401082-NIC-2Gene Knockouth0
(0)

HNF CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

HNF-1α CRISPR Activation Plasmid (h)

sc-400594-ACTGene Activationh0
(0)

HNF-1α CRISPR Activation Plasmid (h2)

sc-400594-ACT-2Gene Activationh0
(0)

HNF-1β CRISPR Activation Plasmid (h)

sc-400537-ACTGene Activationh0
(0)

HNF-1β CRISPR Activation Plasmid (h2)

sc-400537-ACT-2Gene Activationh0
(0)

HNF-3α CRISPR Activation Plasmid (h)

sc-400743-ACTGene Activationh0
(0)

HNF-3α CRISPR Activation Plasmid (h2)

sc-400743-ACT-2Gene Activationh0
(0)

HNF-3β CRISPR Activation Plasmid (h)

sc-400210-ACTGene Activationh0
(0)

HNF-3β CRISPR Activation Plasmid (h2)

sc-400210-ACT-2Gene Activationh0
(0)

HNF-3β CRISPR Activation Plasmid (m)

sc-420890-ACTGene Activationm0
(0)

HNF-3β CRISPR Activation Plasmid (m2)

sc-420890-ACT-2Gene Activationm0
(0)

HNF-3β Lentiviral Activation Particles (m)

sc-420890-LACGene Activationm0
(0)

HNF-3γ CRISPR Activation Plasmid (h)

sc-401720-ACTGene Activationh0
(0)

HNF-3γ CRISPR Activation Plasmid (h2)

sc-401720-ACT-2Gene Activationh0
(0)

HNF-4α CRISPR Activation Plasmid (m)

sc-420892-ACTGene Activationm0
(0)

HNF-4α CRISPR Activation Plasmid (m2)

sc-420892-ACT-2Gene Activationm0
(0)

HNF-4α Lentiviral Activation Particles (m)

sc-420892-LACGene Activationm0
(0)

HNF-4α Lentiviral Activation Particles (m2)

sc-420892-LAC-2Gene Activationm0
(0)

HNF-6 CRISPR Activation Plasmid (h)

sc-401082-ACTGene Activationh0
(0)

HNF-6 Lentiviral Activation Particles (h)

sc-401082-LACGene Activationh0
(0)