CD20 Background Information CD20 is a leukocyte surface antigen consisting of four transmembrane regions and cytoplasmic N- and C-termini. The cytoplasmic domain of CD20 contains multiple phosphorylation sites, leading to additional isoforms. CD20 is expressed primarily on B cells but has also been detected on both normal and neoplastic T cells (2). CD20 functions as a calcium-permeable cation channel, and it is known to accelerate the G0 to G1 progression induced by IGF-1 (3). CD20 is activated by the IGF-1 receptor via the alpha subunits of the heterotrimeric G proteins (4). Activation of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loop-helix leucine zipper transcription factors (5,6).
CD20 (B-H20)
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CD20 (B-H20): sc-65298. Indirect FCM analysis of human peripheral blood leukocytes stained with CD20 (B-H20), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Quadrant markers were set based on the isotype control, normal mouse IgG2a: sc-3878.
