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nucleobindin 2 Antibody (M-17): sc-65160

 |  Datasheet

(Based on data analysis)

  • nucleobindin 2 Antibody (M-17) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the C-terminus of nucleobindin 2 of mouse origin
  • recommended for detection of nucleobindin 2 of mouse, rat and human origin by WB, IF and ELISA
  • blocking peptide, sc-65160 P
 

See additional Nucleobindin Antibodies including Nucleobindin and nucleobindin 2.

Ordering InformationGene Info
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
nucleobindin 2 Antibody (M-17) sc-65160 200 µg/ml $279
nucleobindin 2 (M-17) P sc-65160 P
(peptide)
100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
nucleobindin 2 siRNA (h) sc-62705 10 µM $258
nucleobindin 2 siRNA (m) sc-62706 10 µM $258
nucleobindin 2 (h)-PR sc-62705-PR 10 µM, 20 µl $23
nucleobindin 2 (m)-PR sc-62706-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
nucleobindin 2 shRNA Plasmid (h) sc-62705-SH 20 µg $520
nucleobindin 2 shRNA Plasmid (m) sc-62706-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
nucleobindin 2 shRNA (h) Lentiviral Particles sc-62705-V 200 µl $625
nucleobindin 2 shRNA (m) Lentiviral Particles sc-62706-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
mouse heart extract sc-2254 500 µg/200 µl $104
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NUCB2 4925 11p15.1 NM_005013 P80303
608020
Mouse Nucb2 53322 7 F1 P81117
N/A
 


Nucleobindin 2, also designated NUCB2 or NEFA, is a 420 amino acid protein that is predominantly expressed in spleen, testis and stomach. It localizes to the Golgi and cisternae of the endoplasmic reticulum (ER) and in the nuclear envelope of neurons in the brain. Nucleobindin 2 contains leucine-zipper and EF-hand motifs, two helix-loop-helix regions, and both a basic and an acidic amino acid region. The leucine zipper structure and the basic amino acid-rich region are responsible for DNA binding. It is a highly charged protein that binds Ca2+ via its EF-hand domains. Nucleobindin 2 is also expressed in the hypothalamic nuclei in rats, which may indicate a role in appetite control. Conversion of nucleobindin 2 to nesfatin-1 in the brain decreases food intake in rats. Nesfatin-1 is identified as a satiety molecule that is involved in mela-nocortin signaling in the hypothalamus.