Clusterin-α (M-18) Antibody: sc-6420

Clusterin-α Background Information
Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (ApoJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, å and ∫, are associated through disulfide bonds. The ∫ subunit (also called ApoJå) corresponds to residues 23-227. The å subunit (also called ApoJ∫) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences ∫-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer’s disease pathogenesis.