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home » Synthesis and Degradation » TACE Antibody / TACE Antibodies » TACE (C-15): sc-6416

TACE (C-15) Antibody: sc-6416

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping at the C-terminus of TACE of human origin
  • recommended for detection of precursor and mature TACE (also designated ADAM17) of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-6416 P
 
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Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ADAM17 6868 2p25.1 NM_003183 P78536
 603639
Mouse Adam17 11491 12 A1.3 Q9Z0F8
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
TACE (C-15) sc-6416 200 µg/ml $279
TACE (C-15) P sc-6416 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TACE siRNA (h) sc-36604 10 µM $258
TACE siRNA (m) sc-36605 10 µM $258
TACE (h)-PR sc-36604-PR 10 µM $23
TACE (m)-PR sc-36605-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TACE shRNA Plasmid (h) sc-36604-SH 20 µg $520
TACE shRNA Plasmid (m) sc-36605-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TACE shRNA (h) Lentiviral Particles sc-36604-V 200 µl $625
TACE shRNA (m) Lentiviral Particles sc-36605-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
BJAB Whole Cell Lysate sc-2207 500 µg/200 µl $104
NAMALWA Cell Lysate sc-2234 500 µg/200 µl $104
MOLT-4 Cell Lysate sc-2233 500 µg/200 µl $104
CCRF-HSB-2 Cell Lysate sc-2265 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104

TACE Background Information
Tumor necrosis factor ∫ (TNF∫), also known as lymphotoxin, is a pleiotropic cytokine. TNFå, also known as cachetin, is a cytokine that binds to the same receptors, producing an array of effects similar to those of TNF∫. TNF∫ and TNFå share 30% amino acid homology and have similar biological activities. TNF∫ is produced by activated lymphocytes, including CD4(+) T helper cell type 1 lymphocytes, CD8(+) lymphocytes and certain B lymphoblastoid cell lines. TNFå is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNF∫ and TNFå can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFå converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFå precursor to release soluble TNFå.

TACE (C-15) Product Citations
See how others have used TACE (C-15): sc-6416 antibody and or TACE (C-15) antibody conjugates.


12 total citations
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TACE (C-15)
Click on image to enlarge
sc-6416
TACE (C-15): sc-6416. Western blot analysis of TACE expression in BJAB (A), NAMALWA (B), MOLT-4 (C), CCRF-HSB-2 (D) and K-562 (E) whole cell lysates.
sc-6416
TACE (C-15): sc-6416. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane and cytoplasmic localization.
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