EEA1 Background Information Early endosomes are cytoplasmic compartments that function in receiving and sorting endocytosed proteins for vesicular transport. EEA1 (early endosome antigen 1) is a peripheral membrane protein that co-localizes with the transferrin receptor and Rab5 on early endosomes. EEA1 contains a calmodulin-binding IQ motif and cysteine rich finger motif necessary for its specific localization to the early endosomes. EEA1 has sequence homology to several yeast proteins that have been implicated in membrane trafficking, including Vps27, Fab1 and Vac1. Evidence suggests a possible role for EEA1 in mediating the regulatory effects of 3'-phosphoinositides on membrane trafficking.
EEA1 (N-19) Product Citations
See how others have used EEA1 (N-19): sc-6415 antibody and or EEA1 (N-19) antibody conjugates.
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EEA1 (N-19)
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Western blot analysis of EEA1 expression in A-431 (A,C) and NIH/3T3 (B,D) whole cell lysates. Antibodies tested include EEA1 (C-15): sc-6414 (A,B) and EEA1 (N-19): sc-6415 (C,D).
EEA1 siRNA (h): sc-35263. Western blot analysis of EEA1 expression in non-transfected control (A) and EEA1 siRNA transfected (B) HeLa cells. Blot probed with EEA1 (N-19): sc-6415. α-actinin (H-2): sc-17829 used as specificity and loading control.
