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EB1 Antibody (C-20): sc-6412

 |  Datasheet

(Based on data analysis)

  • EB1 Antibody (C-20) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the C-terminus of EB1 of human origin
  • recommended for detection of EB1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-6412 P
  • See 1 citations for EB1 Antibody (C-20)
 

See additional EB1 Antibodies.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
EB1 Antibody (C-20) sc-6412 200 µg/ml $279
EB1 (C-20) P sc-6412 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
EB1 siRNA (h) sc-35258 10 µM $258
EB1 siRNA (m) sc-35257 10 µM $258
EB1 (h)-PR sc-35258-PR 10 µM, 20 µl $23
EB1 (m)-PR sc-35257-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
EB1 shRNA Plasmid (h) sc-35258-SH 20 µg $520
EB1 shRNA Plasmid (m) sc-35257-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
EB1 shRNA (h) Lentiviral Particles sc-35258-V 200 µl $625
EB1 shRNA (m) Lentiviral Particles sc-35257-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SW480 Cell Lysate sc-2219 500 µg/200 µl $104
COLO 320DM Cell Lysate sc-2226 500 µg/200 µl $104
HISM Cell Lysate sc-2229 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MAPRE1 22919 20q11.21 NM_012325 Q15691
 603108
Mouse Mapre1 13589 2 H1 Q61166
 N/A
 

EB1 (MAPRE2, microtubule-associated protein, RP/EB family, member 2, EB2, RP1) may influence tumorigenesis of colorectal cancers and proliferative control of normal cells. EB1 belongs to the intermediate/early gene family, involved in the signal transduction cascade downstream of the T cell receptor (TRC). Colorectal cancer is caused by the pathologic transformation of normal colonic epithelium to an adenomatous polyp, which can become an invasive cancer. APC (adenomatous polyposis coli) is a tumor suppressor gene, the mutation of which is one of the earliest events in colorectal carcinogenesis. A majority of the mutations result in the loss of the carboxy terminus of APC. EB1 has been shown to bind to the carboxy terminal region of APC, which implicates EB1 in APC suppression of colonic cancer. EB1 overexpression may play a role in the development of human esophageal squamous cell carcinoma by affecting APC function and activating the ∫-catenin/TCF pathway.

EB1 Antibody (C-20) Product Citations
See how others have used EB1 Antibody (C-20) and or EB1 Antibody (C-20) conjugates.


1 total citations
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EB1 Antibody (C-20) Data
Click on image to enlarge
sc-6412
EB1 (C-20): sc-6412. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic staining.
sc-6412
EB1 (C-20): sc-6412. Western blot analysis of EB1 expression in SW480 (A), COLO 320DM (B), HISM (C), LS1034 (D), NIH/3T3 (E) and HeLa (F) whole cell lysates.
sc-6412
EB1 (C-20): sc-6412. Western blot analysis of EB1 expression in non-transfected: sc-117752 (A) and human EB1 transfected: sc-177161 (B) 293T whole cell lysates.
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