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home » Transcription Regulators » IRF Antibody / IRF Antibodies » IRF-1 (M-20): sc-640

IRF-1 (M-20) Antibody: sc-640

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope mapping at the C-terminus of IRF-1 of mouse origin
  • recommended for detection of IRF-1 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF, IHC(P) and ELISA
  • blocking peptide, sc-640 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-640 X, 200 µg/0.1 ml
 
Additional IRF Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human IRF1 3659 5q31.1 NM_002198 P10914
 153550
Mouse Irf1 16362 11 B1.3 P15314
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-1 (M-20) sc-640 200 µg/ml $279
IRF-1 (M-20) P sc-640 P
(peptide)
 100 µg/0.5 ml $61
IRF-1 (M-20) X sc-640 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-1 siRNA (m) sc-35707 10 µM $258
IRF-1 siRNA (m2) sc-156156 10 µM $258
IRF-1 (m)-PR sc-35707-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-1 shRNA Plasmid (m) sc-35707-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-1 shRNA (m) Lentiviral Particles sc-35707-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RAW 264.7 + IFN-γ Cell Lysate sc-2259 500 µg/200 µl $104
RAW 264.7 Whole Cell Lysate sc-2211 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
Jurkat nuclear extract sc-2132 1000 µg $143

IRF-1 Background Information
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-å and ∫) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-å and interferon-∫ genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3© p48 (a component of the ISGF-3 complex) and IFN consensus sequence-binding protein (ICSBP).

IRF-1 (M-20) Product Citations
See how others have used IRF-1 (M-20): sc-640 antibody and or IRF-1 (M-20) antibody conjugates.


40 total citations
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IRF-1 (M-20)
Click on image to enlarge
sc-640
IRF-1 (M-20): sc-640. Western blot analysis of IRF-1 expression in whole cell lysates prepared from IFN-γ-induced (A) and control (B) RAW 264.7 cells.
sc-640
IRF-1 (M-20): sc-640. Immunoperoxidase staining of formalin-fixed, paraffin-embedded mouse uterus tissue showing nuclear localization.
sc-640
IRF-1 (M-20): sc-640. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing nuclear localization.
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