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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Gfi-1 of mouse origin
- recommended for detection of Gfi-1 and Gfi-1B of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-6357 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-6357 X, 200 µg/0.1 ml
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Gfi-1 Background Information
Growth factor independent 1 (Gfi-1) is a transcriptional repressor that specifically binds to the DNA consensus sequence TAAATCAC(A/T)GCA. The carboxy-terminus of Gfi-1 contains six C2H2-type zinc finger motifs, and zinc fingers 3, 4 and 5 are required for the binding of Gfi-1 to its DNA binding site. Gfi-1 also contains a 20 amino acid SNAG domain which mediates transcriptional repression. It represses Bax at the mRNA and protein levels, resulting in the inhibition of cell death. Gfi1 is expressed outside the lymphoid system in granulocytes and activated macrophages. Gfi-1B, a related protein, is a transcriptional repressor primarily expressed in bone marrow and spleen. Gfi-1B is a direct repressor of the p21 promoter and the Socs 1 and 3 promoters. The genes encoding human Gfi-1 and Gfi-1B map to chromosome 1p22 and 9q34.3, respectively.
| Gfi-1 (M-19) Product Citations |
See how others have used Gfi-1 (M-19): sc-6357 antibody and or Gfi-1 (M-19) antibody conjugates.
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Gfi-1 (M-19)
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Gfi-1 (M-19): sc-6357. Western blot analysis of Gfi-1 expression in non-transfected: sc-117752 (A) and human Gfi-1 transfected: sc-115318 (B) 293T whole cell lysates. |
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