epitope mapping at the N-terminus of CDP of mouse origin
recommended for detection of CDP of mouse, rat and human origin by ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-6328 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-6328 X, 200 µg/0.1 ml
CDP Background Information CDP (for CCAAT displacement protein) has been identified as a repressor for transcription of developmentally regulated genes. It is a homeodomain protein that appears to compete with transcriptional activating proteins for binding to the promoter regions of various genes. CDP contains three cut repeats which function as DNA binding domains. It has been demonstrated that cut repeat domains have the capacity to bind to DNA in conjunction with or independently of homeodomain DNA binding. CDP has been shown to be the DNA-binding subunit of the HiNF-D complex, which contains cyclin A, Cdc2 and an Rb-related protein, in addition to CDP. Histone expression is required for the transition to S phase in the cell cycle. The HiNF-D complex regulates the transcription of histone H4, H3 and H1 genes, allowing cells to progress from G1 to S phase.
