Cytokeratin 19 Antibody (A53-B/A2): sc-6278

Cytokeratin 19 Antibody (A53-B/A2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cytokeratin 19 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Cytokeratin 19 antibody (A53-B/A2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cytokeratin 19, a member of the cytokeratin family, is primarily located in the suprabasal layers of squamous epithelium, where Cytokeratin 19 plays a vital role in maintaining structural integrity and mechanical resilience of epithelial cells. This localization allows Cytokeratin 19 to function effectively in providing support during cellular stress and injury, contributing to overall epithelial tissue health. Expression of Cytokeratin 19 is often upregulated in various malignancies, making Cytokeratin 19 a valuable biomarker for diagnosing conditions such as hepatoma and lung cancer. Elevated levels of Cytokeratin 19 fragments in serum have been associated with tumor presence, highlighting significance in clinical diagnostics. Cytokeratin 19′s ability to serve as a marker for dysplasia and carcinoma in situ further underscores importance in cancer research and pathology, providing insights into tumor differentiation and progression.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 19 Antibody (A53-B/A2) has 97 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 19 Antibody (A53-B/A2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 19 Antibody (A53-B/A2) Specifications

Alternate Product Name: KRT19

Product Clone Name: A53-B/A2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 312-335

Epitope Target: Cytokeratin 19

Epitope Species: human

Product Reactivity/Detection: amino acids 312-335 of Cytokeratin 19

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 97 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 19 Antibody (A53-B/A2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Cytokeratin 19 antibody is Cytokeratin 19 Antibody (A-3): sc-376126.