CD74 Background Information The human histocompatibility leukocyte antigen (HLA) class II-associated invariant chain is composed of at least four polypeptides (1-3). One of these polypeptide chains is expressed as a membrane-bound subunit and has been designated CD74 (4,5). The loading of peptide onto the class II MHC protein (MHC II) appears to be regulated by CD74, which associates with MHC II during its migration to the endosomal compartment, where class II binds pep-tide (1). CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages (6). In fact, CD74 is broadly expressed in normal B lymphocytes, regardless of their histocompatibility leukocyte antigen (HLA) phenotype, while a subset of peripheral T lymphocytes that are MHC II negative do not express CD74 (6).
CD74 (LN-2) Product Citations
See how others have used CD74 (LN-2): sc-6262 antibody and or CD74 (LN-2) antibody conjugates.
2 total citations
Loading citations.
CD74 (LN-2)
Click on image to enlarge
CD74 (LN-2): sc-6262. Immunoperoxidase staining of formalin-fixed, paraffin-embedded normal human spleen showing membrane staining (A). Immunofluorescence staining of methanol-fixed Ramos cells showing membrane localization (B).
CD74 (LN-2): sc-6262. Western blot analysis of CD74 expression in BJAB whole cell lysate.
CD74 (LN-2) PE: sc-6262 PE. FCM analysis of Daudi cells. Black line histogram represents the isotype control, normal mouse IgG1: sc-2866.
CD74 (LN-2): sc-6262. Western blot analysis of CD74 expression in non-transfected: sc-117752 (A) and human CD74 transfected: sc-175300 (B) 293T whole cell lysates.
CD74 (LN-2) FITC: sc-6262 FITC. FCM analysis of Daudi cells. Black line histogram represents the isotype control, normal mouse IgG1: sc-2855.
