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home » Tumor Suppressors/Apoptosis » Lamin Antibody / Lamin Antibodies » Lamin A/C (N-18): sc-6215

Lamin A/C (N-18) Antibody: sc-6215

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping at the N-terminus of Lamin A of human origin
  • recommended for detection of Lamin A and Lamin C of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-6215 P
 
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Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human LMNA 4000 1q22 NM_005572, NM_170707, NM_170708 P02545
 608056
Mouse Lmna 16905 3 F1 P48678
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Lamin A/C (N-18) sc-6215 200 µg/ml $279
Lamin A/C (N-18) P sc-6215 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Lamin A/C siRNA (h) sc-35776 10 µM $258
Lamin A/C siRNA (m) sc-29385 10 µM $258
Lamin A/C (h)-PR sc-35776-PR 10 µM $23
Lamin A/C (m)-PR sc-29385-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Lamin A/C shRNA Plasmid (h) sc-35776-SH 20 µg $520
Lamin A/C shRNA Plasmid (m) sc-29385-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Lamin A/C shRNA (h) Lentiviral Particles sc-35776-V 200 µl $625
Lamin A/C shRNA (m) Lentiviral Particles sc-29385-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CCD-1064Sk Cell Lysate sc-2263 500 µg/200 µl $104
Hs68 Cell Lysate sc-2230 500 µg/200 µl $104
FHs 173We Cell Lysate sc-2417 500 µg/200 µl $104
HeLa + staurosporine Cell Lysate sc-24698 500 µg/200 µl $104
Lamin A (h): 293T Lysate sc-177452 100µg/200µl $205
Lamin A (h2): 293T Lysate sc-177453 100µg/200µl $205
Hs68 + AP Cell Lysate sc-24706 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

Lamin A/C Background Information
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/ICE, is comprised of ICE, CPP32, ICH-1/Nedd-2, Tx, Mch2, Mch3 (ICE-LAP3 or CMH-1), Mch4 and ICE-LAP6. Ced-3/ICE family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology. The nuclear Lamin A is cleaved by Mch2, but not CPP32. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family. Lamin C is a splice variant of Lamin A, differing only at the carboxy-terminus. Lamins A and C are identical for the first 566 amino acids, with Lamin C differing only in six unique carboxy-terminal amino acids.

Lamin A/C (N-18) Product Citations
See how others have used Lamin A/C (N-18): sc-6215 antibody and or Lamin A/C (N-18) antibody conjugates.


48 total citations
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Lamin A/C (N-18)
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sc-6215
Lamin A/C (N-18): sc-6215. Western blot analysis of Lamin A/C expression in FSH 173 (A) and Hs68 (B) whole cell lysates.
sc-6215
Lamin A/C (N-18): sc-6215. Immunofluorescence staining of methanol-fixed FHs 173We cells showing nuclear envelope localization.
sc-6215
Lamin A/C (N-18): sc-6215. Western blot analysis of Lamin A/C expression in Hs68 (A), CCD-1064Sk (B) and HeLa (C) whole cell lysates.
sc-6215
Lamin A/C (N-18): sc-6215. Immunofluorescence staining of transgenic Drosophila salivary gland nucleus expressing human Lamin A. Confocal section shows nuclear rim localization. Courtesy of Schulze, S.R. and Wallrath, L.L.W. unpublished.
sc-6215
Lamin A/C (N-18): sc-6215. Immunofluorescence staining of transgenic Drosophila salivary gland nucleus expressing human Lamin A. Confocal composite shows nuclear surface localization. Courtesy of Schulze, S.R. and Wallrath, L.L.W. unpublished.
sc-6215
Lamin A/C (N-18): sc-6215. Immunofluorescence staining of transgenic Drosophila imaginal disc mitotic nuclei expressing human Lamin A. Confocal image courtesy of Schulze, S.R. and Wallrath, L.L.W. unpublished.
sc-6215
Lamin A/C (N-18): sc-6215. Western blot analysis of Lamin A/C expression in non-transfected 293T: sc-117752 (A), mouse Lamin A/C transfected 293T: sc-121279 (B) and HeLa (C) whole cell lysates.
sc-6215
Lamin A/C (N-18): sc-6215. Western blot analysis of Lamin A expression in non-transfected 293T: sc-117752 (A), human Lamin A transfected 293T: sc-177452 (B) and Hs68 (C) whole cell lysates.
sc-6215
Lamin A/C (N-18): sc-6215. Western blot analysis of Lamin A expression in non-transfected 293T: sc-117752 (A), human Lamin A transfected 293T: sc-177453 (B) and Hs68 (C) whole cell lysates.
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