epitope mapping near the N-terminus of Smad2 of human origin
recommended for detection of Smad2 of mouse, rat, human and mink origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
blocking peptide, sc-6200 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-6200 X, 200 µg/0.1 ml
Smad2 Background Information Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad proteins.
Smad2 (S-20) Product Citations
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Smad2 (S-20)
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Smad2 (S-20): sc-6200. Western blot analysis of Smad2 expression in non-transfected: sc-117752 (A) and human Smad2 transfected: sc-114131 (B) 293T whole cell lysates.
Smad2 (S-20): sc-6200. Western blot analysis of Smad2 expression in non-transfected: sc-117752 (A) and human Smad2 transfected: sc-113452 (B) 293T whole cell lysates.
Smad2 (S-20): sc-6200. Western blot analysis of Smad2 expression in non-transfected: sc-117752 (A) and mouse Smad2 transfected: sc-123638 (B) 293T whole cell lysates.
