epitope mapping at the N-terminus of FKBP12 of human origin
recommended for detection of FKBP12 and FKBP12.6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine, porcine and avian
FKBP12 Background Information Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. The prototypic member of the family, FKBP12, was originally identified as a target of FK506 and Rapamycin activity. FKBP12 is an abundant, evolutionarily conserved cytoplasmic protein. Although the molecular role of FKBP12 activity is not well understood, the protein has been implicated as a regulator of diverse array of cellular processes including T cell activation, entry into the cell cycle and intracellular calcium release. Interestingly, FKBP12 has been shown to associate with the intracellular cytoplasmic domain of the type I TGF∫ receptor. This association is constitutive and not dependent on the activation of the receptor.
FKBP12 (N-19) Product Citations
See how others have used FKBP12 (N-19): sc-6174 antibody and or FKBP12 (N-19) antibody conjugates.
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FKBP12 (N-19)
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FKBP12 (N-19): sc-6174. Western blot analysis of FKBP12 expression in U-937 (A) whole cell lysate and mouse brain (B) extract.
FKBP12 (N-19): sc-6174. Western blot analysis of FKBP12 expression in non-transfected: sc-117752 (A) and mouse FKBP12 transfected: sc-126858 (B) 293T whole cell lysates.
