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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of ICSBP of mouse origin
- recommended for detection of ICSBP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine and bovine
- blocking peptide, sc-6058 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-6058 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
IRF8 |
3394 |
16q24.1 |
NM_002163 |
Q02556
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601565 |
| Mouse |
Irf8 |
15900 |
8 E1 |
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P23611
|
N/A |
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ICSBP Background Information
ICSBP (Interferon (IFN) consensus sequence-binding protein, Interferon regulatory factor 8; IRF-8) is a transcription factor that is important for IFN-©-mediated signaling during dendritic cell and macrophage differentiation. ICSBP physically interacts with TRAF6 (between amino acid residues 356 and 305), and this interaction of ICSBP with TRAF6 modulates TLR signaling and may contribute to the cross-talk between IFN-© and TLR signal pathways. ICSBP antagonizes Bcr/Abl by downregulation of Bcl-2. ICSBP is known to interact with chromatin, and bind PU.1 in macrophages. ICSBP belongs to the IFN regulatory factor (IRF) family that also includes IRF-1, IRF-2, and ISGF-3. These proteins are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of IFN-å and IFN-∫.
| ICSBP (C-19) Product Citations |
See how others have used ICSBP (C-19): sc-6058 antibody and or ICSBP (C-19) antibody conjugates.
20 total citations Loading citations.
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ICSBP (C-19)
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ICSBP (C-19): sc-6058. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil showing nuclear staining.
ICSBP siRNA (h): sc-35630. Western blot analysis of ICSBP expression in non-transfected control (A) and ICSBP siRNA transfected (B) BJAB cells. Blot probed with ICSBP (C-19): sc-6058. Actin (I-19): sc-1616 used as specificity and loading control. ICSBP (C-19): sc-6058. Western blot analysis of ICSBP expression in non-transfected: sc-117752 (A) and mouse ICSBP transfected: sc-120937 (B) 293T whole cell lysates. ICSBP (C-19): sc-6058. Western blot analysis of IFN consensus sequence-binding proteins in BJAB (A), Ramos (B) and NAMALWA (C) whole cell lysates.
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