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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of Fra-2 of human origin
- recommended for detection of Fra-2 of mouse, rat, human and chicken origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine and bovine
- blocking peptide, sc-604 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-604 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
FOSL2 |
2355 |
2p23.2 |
NM_005253 |
P15408
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601575 |
| Mouse |
Fosl2 |
14284 |
5 B1 |
|
P47930
|
N/A |
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Fra-2 Background Information
The Fos-related gene Fra-2 was initially molecularly cloned from chicken genomic DNA and shown to represent a new member of the immediate early gene family. The human counterpart of the chicken Fra-2 gene has been described. Sequence alignment shows that the amino acid sequences conserved among Fra-2, c-Fos, Fra-1 and Fos B are contained in five regions. Region 2, the longest and most highly conserved region, contains the leucine zipper structure and the basic region, suggesting that like Fos, Fra-1 and Fos B, Fra-2 also forms heterodimers with c-Jun that recognize specific DNA sequences, such as the binding site for transcription factor AP-1. Such a model is further supported by the finding that the Fra-2 gene product forms a complex with c-Jun in growth-stimulated cells.
| Fra-2 (Q-20) Product Citations |
See how others have used Fra-2 (Q-20): sc-604 antibody and or Fra-2 (Q-20) antibody conjugates.
76 total citations Loading citations.
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Fra-2 (Q-20)
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Fra-2 (Q-20): sc-604. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate carcinoma tissue showing nuclear localization.
Western blot analysis of Fra-2 expression in NIH/3T3 nuclear extracts (A,B). Antibodies tested include Fra-2 (L-15): sc-171 (A) and Fra-2 (Q-20): sc-604 (B). Fra-2 (Q-20): sc-604. Immunofluorescence staining of normal mouse intestine frozen section showing nuclear staining.
Fra-2 (Q-20): sc-604. Western blot analysis of Fra-2 expression in non-transfected: sc-117752 (A) and human Fra-2 transfected: sc-176490 (B) 293T whole cell lysates. Fra-2 (Q-20): sc-604. Western blot analysis of Fra-2 expression in non-transfected 293T: sc-117752 (A), human Fra-2 transfected 293T: sc-176490 (B) and NTERA-2 cl.D1 (C) whole cell lysates. Fra-2 (Q-20): sc-604. Western blot analysis of Fra-2 expression in non-transfected 293T: sc-117752a (A), human Fra-2 transfected 293T: sc-176435 (B) and MCF7 (C) whole cell lysates. Fra-2 (Q-20): sc-604. Immunoperoxidase staining of formalin fixed, paraffin-embedded human esophagus tissue showing nuclear and cytoplasmic staining of squamous epithelial cells.
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