pan CEA Antibody (D14HD11): sc-59874
- pan CEA Antibody (D14HD11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against CEA of human origin
- recommended for detection of a broad range of CEACAM family members on transfectants of human origin by WB, IP, IF, IHC(P) and FCM; not recommended for detection of CEACAM7 and CD67
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for pan CEA Antibody (D14HD11) for WB and IHC(P) applications. These reagents are now offered in bundles with pan CEA Antibody (D14HD11) (see ordering information below).
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pan CEA Antibody (D14HD11) is a mouse monoclonal IgG1 antibody that detects carcinoembryonic antigen (CEA) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-CEA antibody (D14HD11) plays a crucial role in cancer diagnostics, as CEA is one of the most widely utilized tumor markers in serum immunoassays for carcinoma detection. CEA is primarily located on the cell surface and is involved in cell adhesion processes, which are vital for maintaining tissue architecture and facilitating communication between cells. This localization is particularly important in tumor biology, as alterations in cell adhesion can lead to increased tumor invasiveness and metastasis. Additionally, CEA is part of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family, which includes several members that contribute to various cellular functions, such as angiogenesis and immune response modulation. Human CEACAM proteins are encoded by genes clustered on chromosome 19, and their expression levels can provide significant insights into tumor progression and patient prognosis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
pan CEA Antibody (D14HD11) References:
- Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies. | Sheahan, K., et al. 1990. Am J Clin Pathol. 94: 157-64. PMID: 1695478
- A comprehensive phylogenetic and structural analysis of the carcinoembryonic antigen (CEA) gene family. | Pavlopoulou, A. and Scorilas, A. 2014. Genome Biol Evol. 6: 1314-26. PMID: 24858421
- Immunohistochemical detection of carcinoembryonic antigen (CEA) in non-cancerous and cancerous gastric mucosa. | Nasierowska-Guttmejer, A. and Szawlowski, AW. 1989. Int J Biol Markers. 4: 8-12. PMID: 2664022
- Carcinoembryonic antigen (CEA) and alkaline phosphatase in progressive colorectal cancer with special reference to patient survival. | Aabo, K., et al. 1986. Eur J Cancer Clin Oncol. 22: 211-7. PMID: 3699082
- Diagnostic performance of intracystic carcinoembryonic antigen (CEA) versus glucose in differentiation of mucinous and non-mucinous pancreatic cysts. | Gyimesi, G., et al. 2024. Pathol Oncol Res. 30: 1611881. PMID: 39449683
- Carcinoembryonic antigen (CEA) in patients with alcoholic liver diseases. | Bell, H., et al. 1979. Scand J Gastroenterol. 14: 273-9. PMID: 441676
- Carcinoembryonic antigen (CEA) in diagnosis and prognosis of colorectal carcinoma. | Arnaud, JP., et al. 1980. Dis Colon Rectum. 23: 141-4. PMID: 7379666
- Carcinoembryonic antigen (CEA) in gastric juice or feces as an aid in the diagnosis of gastrointestinal cancer. | Fujimoto, S., et al. 1979. Ann Surg. 189: 34-8. PMID: 758861
- CD66b, CD66c and carcinoembryonic antigen (CEA) are independently regulated markers in sera of tumor patients. | Grunert, F., et al. 1995. Int J Cancer. 63: 349-55. PMID: 7591230
- An evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer. | Moertel, CG., et al. 1993. JAMA. 270: 943-7. PMID: 8141873
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pan CEA Antibody (D14HD11) | sc-59874 | 200 µg/ml | $316.00 | |||
pan CEA Antibody (D14HD11): m-IgG Fc BP-HRP Bundle | sc-539148 | 200 µg Ab; 10 µg BP | $354.00 | |||
pan CEA Antibody (D14HD11): m-IgG1 BP-HRP Bundle | sc-541294 | 200 µg Ab; 20 µg BP | $354.00 |