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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of CtBP2 of human origin
- recommended for detection of CtBP2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine, porcine and avian
- blocking peptide, sc-5967 P
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CtBP2 Background Information
CtBP1 is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. CtBP1 and the related protein CtBP2 are characterized as C-terminal binding protein of adenovirus E1A, and they preferentially associate with the E1A via a 5-amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T-cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of deltaEF1, a cellular zinc finger-homeodomain protein, and thereby enhance deltaEF1 induced transcriptional silencing. In addition, CtBP complexes with CtIP, a protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. CtIP/CtBP binding to BRCA1 inhibits the transactivation of the p21 promoter, and it is critical for regulating p21 transcription in response to DNA damage. |
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CtBP2 (C-16)
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CtBP2 (C-16): sc-5967. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
CtBP2 (C-16): sc-5967. Western blot analysis of CtBP2 expression in non-transfected: sc-117752 (A) and mouse CtBP2 transfected: sc-126676 (B) 293T whole cell lysates. |
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