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home » Transcription Regulators » CtBP Antibody / CtBP Antibodies » CtBP1 (K-15): sc-5961

CtBP1 (K-15) Antibody: sc-5961

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping within an internal region of CtBP1 of human origin
  • recommended for detection of CtBP1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
  • blocking peptide, sc-5961 P
 
Additional CtBP Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CTBP1 1487 4p16.3 NM_001012614, NM_001328 Q13363
 602618
Mouse Ctbp1 13016 5 B1 O88712
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CtBP1 (K-15) sc-5961 200 µg/ml $279
CtBP1 (K-15) P sc-5961 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CtBP1 siRNA (h) sc-35122 10 µM $258
CtBP1 siRNA (m) sc-35121 10 µM $258
CtBP1 (h)-PR sc-35122-PR 10 µM $23
CtBP1 (m)-PR sc-35121-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CtBP1 shRNA Plasmid (h) sc-35122-SH 20 µg $520
CtBP1 shRNA Plasmid (m) sc-35121-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CtBP1 shRNA (h) Lentiviral Particles sc-35122-V 200 µl $625
CtBP1 shRNA (m) Lentiviral Particles sc-35121-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CtBP1 (h): 293T Lysate sc-171371 100µg/200µl $205
KNRK nuclear extract sc-2141 1000 µg $143
HeLa nuclear extract sc-2120 1000 µg $143
CtBP1 (m): 293T Lysate sc-119492 100µg/200µl $205

CtBP1 Background Information
CtBP1 is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. CtBP1 and the related protein CtBP2 are characterized as C-terminal binding protein of adenovirus E1A, and they preferentially associate with the E1A via a 5-amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T-cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of ∂EF1, a cellular zinc finger-homeodomain protein, and thereby enhances ∂EF1 induced transcriptional silencing. In addition, CtBP complexes with CtIP, a protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. CtIP/CtBP binding to BRCA1 inhibits the transactivation of the p21 promoter, and it is critical for regulating p21 transcription in response to DNA damage.

CtBP1 (K-15) Product Citations
See how others have used CtBP1 (K-15): sc-5961 antibody and or CtBP1 (K-15) antibody conjugates.


2 total citations
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CtBP1 (K-15)
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sc-5961
Western blot analysis of CtBP1 expression in KNRK nuclear extracts (A,B). Antibodies tested include CtBP1 (K-15): sc-5961 (A) and CtBP1 (C-17): sc-5963 (B).
sc-5961
CtBP1 (K-15): sc-5961. Western blot analysis of CtBP1 expression in non-transfected: sc-117752 (A) and mouse CtBP1 transfected: sc-119492 (B) 293T whole cell lysates.
sc-5961
CtBP1 (K-15): sc-5961. Western blot analysis of CtBP1 expression in non-transfected: sc-117752 (A) and human CtBP1 transfected: sc-171371 (B) 293T whole cell lysates and HeLa nuclear extract (C).
sc-5961
CtBP1 (K-15): sc-5961. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.
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