recommended for detection of S-100A2 of h and r origin by WB, IP, IF and ELISA; non cross-reactive with other members of the EF-hand family including calmodulin, parvalbumin, intestinal calcium-binding protein, S100A6 (calcyclin), caltropin, the alpha chain of S100 (i.e. in S100a and S100ao), or the beta chain (i.e. in S100a and S100b); also reactive with additional species, including bovine, porcine, feline and canine
S-100A2 Background Information S-100A2 (S100L), first isolated from cow lung, belongs to a large family of calcium binding proteins known as S-100 proteins. S-100A2 is expressed in the basal layer of the epidermis and hair follicles of normal skin. S-100A2 associates with Tropomyosin in a calcium-dependent manner. In breast cancer, S-100A2 expression is lost during the development of malignant cells.
S-100A2 may play a tumor-suppressor role in certain epithelial tissues by intefering with cell migration. S-100A2 exerts an inhibitory influence on cell motility of head and neck squamous cell carnicomas in vitro. Neoplastic gastric epithelial cells express S-100A2 as well as S-100A7, S-100A8,
S-100A9 and S-100A10 in greater abundance than normal gastric cells.
