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NF-L Antibody (NR4): sc-58560

 |  Datasheet

(Based on data analysis)

  • NF-L Antibody (NR4) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against NF-L of porcine origin
  • recommended for detection of NF-L of h and r origin by IF; non cross-reactive with other intermediate filament proteins; also reactive with additional species, including porcine
 

See additional NF Antibodies including NF, NF-H, NF-L and NF-M.

Ordering InformationGene Info
Recommended Support Products:
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IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L Antibody (NR4) sc-58560 200 µg/ml $279
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L CRISPR/Cas9 KO Plasmid (h) sc-402254 20 µg $345
NF-L HDR Plasmid (h) sc-402254-HDR 20 µg $385
NF-L CRISPR/Cas9 KO Plasmid (m) sc-421882 20 µg $345
NF-L HDR Plasmid (m) sc-421882-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L siRNA (h) sc-36048 10 µM $258
NF-L (h)-PR sc-36048-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L shRNA Plasmid (h) sc-36048-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L shRNA (h) Lentiviral Particles sc-36048-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NEFL 4747 8p21.2 NM_006158 P07196
607734
 


Neurofilament-L (NF-L), for neurofilament light polypeptide, a member of the intermediate filament family, is a major component of neuronal cyto-skeletons. Neurofilaments are dynamic structures; they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3 and stress-activated protein kinase gamma. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and Actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease and Alzheimer's disease.