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NF-L Antibody (DA2): sc-58559

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  • NF-L Antibody (DA2) is a mouse monoclonal IgG1 provided at 250 µl supernatant
  • recommended for detection of NF-L of mouse, rat and human origin by WB and IF; also reactive with additional species, including bovine and porcine
  • See 2 citations for NF-L Antibody (DA2)
 

See additional NF Antibodies including NF, NF-H, NF-L and NF-M.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L Antibody (DA2) sc-58559 250 µl supernatant $279
 CRISPR KO, HDR and Nickase Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L CRISPR/Cas9 KO Plasmid (h) sc-402254 20 µg $345
NF-L HDR Plasmid (h) sc-402254-HDR 20 µg $385
NF-L Double Nickase Plasmid (h) sc-402254-NIC 20 µg $355
NF-L Double Nickase Plasmid (h2) sc-402254-NIC-2 20 µg $355
NF-L CRISPR/Cas9 KO Plasmid (m) sc-421882 20 µg $345
NF-L HDR Plasmid (m) sc-421882-HDR 20 µg $385
NF-L Double Nickase Plasmid (m) sc-421882-NIC 20 µg $355
NF-L Double Nickase Plasmid (m2) sc-421882-NIC-2 20 µg $355
 CRISPR Activation Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L CRISPR Activation Plasmid (h) sc-402254-ACT 20 µg $345
NF-L CRISPR Activation Plasmid (h2) sc-402254-ACT-2 20 µg $345
NF-L Lentiviral Activation Particles (h) sc-402254-LAC 200 µl $395
NF-L Lentiviral Activation Particles (h2) sc-402254-LAC-2 200 µl $395
NF-L CRISPR Activation Plasmid (m) sc-421882-ACT 20 µg $345
NF-L CRISPR Activation Plasmid (m2) sc-421882-ACT-2 20 µg $345
NF-L Lentiviral Activation Particles (m) sc-421882-LAC 200 µl $395
NF-L Lentiviral Activation Particles (m2) sc-421882-LAC-2 200 µl $395
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L siRNA (h) sc-36048 10 µM $258
NF-L siRNA (m) sc-36049 10 µM $258
NF-L (h)-PR sc-36048-PR 10 µM, 20 µl $23
NF-L (m)-PR sc-36049-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L shRNA Plasmid (h) sc-36048-SH 20 µg $520
NF-L shRNA Plasmid (m) sc-36049-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NF-L shRNA (h) Lentiviral Particles sc-36048-V 200 µl $625
NF-L shRNA (m) Lentiviral Particles sc-36049-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
mouse brain extract sc-2253 500 µg/200 µl $104
SK-N-SH Cell Lysate sc-2410 500 µg/200 µl $104
SH-SY5Y Cell Lysate sc-3812 500 µg/200 µl $104
rat cerebellum extract sc-2398 500 µg/200 µl $104
rat brain extract sc-2392 500 µg/200 µl $104
IMR-32 Cell Lysate sc-2409 500 µg/200 µl $104
NF-L (h2): 293T Lysate sc-159429 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NEFL 4747 8p21.2 NM_006158 P07196
607734
Mouse Nefl 18039 14 D1 P08551
N/A
 


Neurofilament-L (NF-L), for neurofilament light polypeptide, a member of the intermediate filament family, is a major component of neuronal cyto-skeletons. Neurofilaments are dynamic structures; they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3 and stress-activated protein kinase gamma. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and Actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease and Alzheimer's disease.

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NF-L Antibody (DA2) Product Reviews

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NF-L Antibody (DA2) Product Citations
See how others have used NF-L Antibody (DA2) and or NF-L Antibody (DA2) conjugates.


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NF-L Antibody (DA2) Data
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NF-L (DA2): sc-58559. Western blot analysis of NF-L expression in rat brain tissue extract.
NF-L (DA2): sc-58559. Immunofluorescence staining of methanol-fixed adult rat brain cells showing neuronal localization (green).
NF-L (DA2): sc-58559. Western blot analysis of NF-L expression in rat spinal cord cell extract.
NF-L (DA2): sc-58559. Western blot analysis of NF-L expression in non-transfected: sc-117752 (A) and human NF-L transfected: sc-159429 (B) 293T whole cell lysates.
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