epitope mapping near the C-terminus of Amphiregulin of human origin
recommended for detection of precursor and mature Amphiregulin of mouse, rat and human origin by WB, IP, IF and ELISA; cross reactive with Amphiregulin B
Amphiregulin Background Information Epidermal growth factor (EGF) family member Amphiregulin was initially characterized as a schwannoma-derived growth factor (SDGF) that was expressed in response to androgen in the SC2G murine cell line. Amphiregulin has subsequently been characterized as an important growth factor for normal human keratinocyte proliferation. Amphiregulin is produced and secreted by keratinocytes and acts as an autocrine growth factor. Amphiregulin binds ErbB-1, which is essential for epithelial development in the skin, lung and gastrointestinal tract. Withdrawl of Amphiregulin has been shown to result in down regulation of telomerase activity in human keratinocytes and this suggests that Amphiregulin plays a role in cell senescence.
Amphiregulin (C-13) Product Citations
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Amphiregulin (C-13)
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Amphiregulin (C-13): sc-5796. Western blot analysis of Amphiregulin expression in non-transfected: sc-110760 (A) and Amphiregulin transfected (B) 293T whole cell lysates.
