Nucleolar Marker (31C4) Antibody: sc-57947

Nucleolar Marker Background Information
The nucleolus, which lies within the nucleus, is the site of the production and assembly of ribosome components. It is also responsible for trafficking various prominent small RNA species during their maturation process and facilitating the route to their final cellular destination. The nucleolus may also have a role in cell cycle regulation, regulation of tumor suppressor and oncogene activities, signal recognition particle assembly, modification of small RNA strands, and control of aging and modulating telomerase function. The nucleolus, which is roughly spherical, is surrounded by a layer of condensed chromatin; it is not separated from the nucleoplasm by any type of membrane. The nucleolus is made up of fibrillar centers (FC), dense fibrillar components (DFC), granular components (GC) and ribosomal DNA. It contains unique proteins that may function as markers in nucleolar research applications.